Platelet-rich plasma, or PRP, is a natural alternative to repairing bone, joint, and tissue damage. It is generally cheaper than surgery with a much quicker post-op recovery time. PRP includes a reduced risk of an allergic reaction and bodily rejection than a more invasive, surgical operation. During PRP, the patient’s blood is drawn and then centrifuged in order to separate red blood cells from the blood plasma. Following further extraction and platelet activation, the initiated plasma is injected into the areas of the patient where the cellular repair is desired.

Exosomes are cell-derived endomembrane vesicles that are present in a majority of eukaryotic cells in the human body. They are comprised of lipids, proteins, and mRNA which can be transferred to surrounding cells in order to nourish or communicate with them. They are derived from mesenchymal stem cells (MSC’s) which have been shown to be well tolerated by the immune system which makes for effective and safe drug delivery. ‘MSCs’ are more commonly referred to as ‘Medicinally Signaling Cells.’ They have an immense capacity for cell-to-cell communication which is their principal mechanism of action. These therapeutic cells act in two steps. They primarily locate sites of injury and sequentially secrete bioactive factors that are immunomodulatory as well as regenerative. Following injection, exosomes will act in their microenvironment to communicate with local cells via paracrine (local) signaling. 

What is PRP / Exosome Therapy Used For?

PRP with Exosome therapy has a number of applications. Exosomes, if included in a PRP procedure, can actually provide a synergistic effect in the healing process as earlier mentioned. PRP acts by creating new blood vessels that generate a greater flow of growth factors and nourishing blood to the desired area. When combined with exosomes, the damaged tissues can better communicate with the already healthy ones which promote an even higher degree of healing. 

This adjunctive therapy can be used cosmetically to treat acne, rosacea, and wrinkled skin. Therapies can be used to address hair loss, osteoarthritis, sports injuries, erectile dysfunction, urinary incontinence, and overall sexual wellness. It can even be used in patients who have recently undergone surgery to promote tissue regrowth. Due to its versatility and effectiveness, it’s no wonder that this procedure has become so popular.


What Are the Potential Side Effects of PRP Exosome Therapy?

Generally speaking, PRP comes with fewer risks than many other types of medical procedures. Since the plasma used comes directly from the patient, the likelihood of any type of adverse reaction or rejection is much lesser. In addition, this minimally invasive treatment is accompanied by little (if any) discomfort and requires minimal downtime for recovery.

That said, every medical procedure does have potential side effects. While these side effects are relatively rare, it’s essential that patients fully understand the risks prior to undergoing PRP. The plasma itself will produce no negative reaction in a patient, but any kind of injection may offer a risk of infection, pain, nerve injuries, or tissue damage — particularly at the injection site. Blood clots and skin discoloration may also be a concern. 

It’s also important to keep in mind that, while PRP is extremely effective, every patient is different. Some patients may not show significant improvement after this treatment, so it’s important to discuss all of your options and concerns with your physician prior to undergoing this type of procedure.

Ultimately, the potential side effects associated with PRP are nominal — and the benefits you stand to gain are significant. To learn more about PRP, Exosomes, or any other questions, please contact Foster Medical today.